1-adamantyl-[4-(2-fluorophenyl)-1-piperazinyl]methanone

1-adamantyl-[4-(2-fluorophenyl)-1-piperazinyl]methanone, also known as **WAY-100635**, is a potent and selective antagonist of the **dopamine D3 receptor**.

**Importance for Research:**

* **Understanding Dopamine D3 Receptor Function:** WAY-100635 is a valuable tool for researchers studying the role of the dopamine D3 receptor in various physiological processes, including:
* **Motivation and Reward:** D3 receptors are highly expressed in brain regions involved in reward and motivation. WAY-100635 helps investigate the role of D3 receptors in these functions.
* **Cognition and Learning:** D3 receptors are also implicated in cognitive processes, and WAY-100635 can be used to examine their involvement in learning and memory.
* **Addiction:** Dysregulation of D3 receptors is linked to addictive behaviors. WAY-100635 has been studied as a potential treatment for substance abuse disorders.
* **Development of Novel Therapeutics:** WAY-100635 is a lead compound in the development of new drugs targeting the D3 receptor. Its high selectivity and potency make it a promising candidate for treating conditions like:
* **Schizophrenia:** D3 receptor antagonists may be effective in treating negative symptoms of schizophrenia.
* **Parkinson's Disease:** D3 receptor antagonists may have potential in managing motor symptoms of Parkinson's disease.
* **Depression and Anxiety:** D3 receptors are involved in mood regulation, and antagonists may have therapeutic benefits for these disorders.

**Note:** Although WAY-100635 has shown promise in preclinical studies, its clinical application is still under investigation. More research is needed to evaluate its efficacy, safety, and optimal dosage for different conditions.